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Formerly Clinical Pharmacokinetics: Concepts and Applications, this fully updated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject. A companion website includes the full text online, plus interactive simulations for student practice using different pharmacokinetic/pharmacodynamic models and parameters.
Hardcover: 864 pages
Publisher: LWW; Fourth edition (January 28, 2010)
Language: English
ISBN-10: 0781750091
ISBN-13: 978-0781750097
Product Dimensions: 7.2 x 1.5 x 9.9 inches
Shipping Weight: 3.8 pounds (View shipping rates and policies)
Average Customer Review: 4.4 out of 5 stars See all reviews (13 customer reviews)
Best Sellers Rank: #137,199 in Books (See Top 100 in Books) #1 in Books > Medical Books > Pharmacology > Pharmacodynamics #101 in Books > Textbooks > Medicine & Health Sciences > Medicine > Basic Sciences > Pharmacology #112 in Books > Textbooks > Medicine & Health Sciences > Medicine > Clinical > Internal Medicine
"Clinical Pharmacokinetics: Concepts and Applications" (or better known as Rowland and Tozer) is a book filled with deep concepts and good explanations. It is the Bible of Pharmacokinetics. If there is a PK concept you want to look up, this book will be the first place you look for it. Before giving the review, let me introduce my background. I have a formal education in physical chemistry and analytical chemistry and am currently working in the field of pharma. I have currently read through half of this book. Although I have not completely finishing the book, I believe there is enough information to share.The previous PK book I read was Concepts In Clinical Pharmacokinetics by Joseph T. Dipiro and it is a shorter and simpler book than Rowland and Tozer. While "Concepts In Clinical Pharmacokinetics" was a delight to read, it is on the simpler side and a lot of concepts are left unexplained. When I was reading it, there were often moment of "How did he get from this to that?" or "Where this comes from?", and I had to stop reading and tried to derive the equations. In contrast, Rowland and Tozer explain the principles of PK in great details and often from multiple angles, so that the readers can fully appreciate how the concepts are linked together, how PK theories apply and how PK impacts pharmacology research and the drug discovery. The exercises are challenging, but not impossible. Well, a few of them are nearly impossible, but most of them can be worked out (even for someone of my background).I would love to give it a 4.5 stars, but that is not an option.
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