File Size: 995 KB
Print Length: 336 pages
Publisher: Farrar, Straus and Giroux (June 7, 2016)
Publication Date: June 7, 2016
Sold by: Macmillan
Language: English
ASIN: B01828N3LE
Text-to-Speech: Enabled
X-Ray: Not Enabled
Word Wise: Enabled
Lending: Not Enabled
Enhanced Typesetting: Enabled
Best Sellers Rank: #67,159 Paid in Kindle Store (See Top 100 Paid in Kindle Store) #4 in Kindle Store > Kindle eBooks > Health, Fitness & Dieting > Counseling & Psychology > Psychopharmacology #5 in Kindle Store > Kindle eBooks > Medical eBooks > Pharmacology > Pain Medicine #15 in Books > Medical Books > Pharmacology > Pain Medicine
One of the first books I read after being diagnosed with depression and social anxiety n 2001 was Listening to Prozac. What I got from that book was that Peter Kramer was skeptical about Prozac, but after years of seeing people in therapy and not progressing, then makeing remarkable progress in Prozac, he came around to its usefulness, although he did question what it meant when it would be so easy to change our personality with a pill.Over the years, the skepticism and blowback against antidepressants has changed the public opinion of them greatly. Like the benzo's and first generation antidepressants, they were first beloved, but then maligned because they were either seen as not much better than a placebo, dangerous, causing suicidality and dependence or simply a product of big pharma greed.Ordinarily well is very much a continuation of Listening to prozac as well as a reaction to a lot of the negative backlash against antidepressants.This book alternates between case studies where Peter describes how his patients healed along with descriptions of controlled studies. He goes into a lot of depth about how and why studies can be flawed, either because they are in a controlled clinical setting, because the patients have failed antidepressants before and are less likely to succeed, because of the imprecise practice of using a scale to calculate depression, because the mere practice of going to a clinical center is therapeutic, because the doctors have a lot of pressure to produce positive results as well as numerous other reasons.
I am a layman who is extremely interested in psychiatry, human cognition, and a broad spectrum of issues in human & animal behavioral science. I have been following the antidepressant debate for quite a while and noticed the general commentary in the media on this topic, even in the more thoughtful outlets, tends to have a significant anti medication bias. There are usually two angles that sometimes tend to contradict each other. Either antidepressants don’t work much better than placebo, or they work, but somehow rob us of feeling and expressing our “natural” emotions.Typically, the media outlets don’t actually engage in thoughtful analysis of these really important questions, but rather (poorly) regurgitate and interpretation of one study or another. Worse yet, science journalists covering this topic repeat silly, red herring clichés such as “isn’t it bad to prescribe antidepressants for someone grieving over a loss of loved one” and so on.Despite this treatment of the antidepressant topic in the media, there are a number of thoughtful blogs (a lot of them from practicing physicians) who tell a much more nuanced story about these drugs. The picture that ultimately emerges is quite different than the angle peddled by the media. It is on one of these blogs, that I discovered Dr. Kramer’s Ordinarily Well: The Case for Antidepressants.I want to start by saying that even if you somehow skip all the sections about the nuances of antidepressant efficacy and just read the remaining sections, you will learn a great deal about modern medicine. What I mean by this is that Dr.
I've previously read "The Emperor's New Drugs" and "Manufacturing Depression" and the arguments in those books mostly convinced me that antidepressants are ineffective.Subsequently, I end up discontinuing them, but the depression that haunted me since my early childhood intensified, at least intermittently, afterwards. And so did the related conditions like Social Anxiety.Eventually, I end up volunteering at a drug study to find an antidepressant that is not just a "placebo" and actually works but after many months as a "guinea pig" in several antidepressant studies I quit without feeling better than on approved antidepressants I've tried before (incidentally, as the book described, many if not most participants I encountered at the research center indeed looked very impoverished and like they were there for the money. To that effect even a notice was a posted by the entrance: "Participants tested positive for drugs won't get paid for your today's appointment")After reading this book I was mostly convinced about SSRI efficacy, but certainly some doubts still linger about its safety, especially long term, as Dr Kramer himself readily admits.The author was less convincing with his jabs at the evidence based medicine. Certainly, the quality of evidence are only as good as the studies that produced them, and there have been a lot of bad studies performed expediently by the Pharma, often, ironically, to their own detrement. Clinical judgment on the other hand could be clouded by the profit motive and hubris , that EBM suppose to keep a check on.
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